DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images and information, contained on or available through this document is for general information purposes only. Please contact your physician to form a plan that addresses you or your loved ones specific needs. Please note that clinical trials are not designed to be treatments for your specific condition. They are designed for research purposes only to determine mechanisms, safety, tolerability, and potential therapeutic efficacy for an experimental drug. The screening and inclusion/exclusion process are very strict and it can be difficult to be selected for enrollment. Being involved in a clinical trial does not guarantee any benefit from the treatment and being a participant in a clinical trial is very time intensive.

Psychedelic Clinical Trials (will be updated soon):

Pulled from clinicaltrials.gov for studies. Click the link for more details about location and inclusion/exclusion criteria for each specific trial. Note we are in the process of updating this. For a more current list, either search clinicaltrials.gov directly, or check out this resource over at Psychedelic.Support.

• Healthy Volunteers

  • LSD

    • Role of the Serotonin 5-HT2A Receptor in LSD-induced Altered States of Consciousness (LDR-Study): LINK

    • Direct Comparison of Altered States of Consciousness Induced by LSD and Psilocybin in a Random-order Placebo-controlled Cross-over Study in Healthy Subjects: LINK

    • Role of Dopamine, Serotonin and 5-HT2A Receptors in Emotion Processing: LINK

  • Cannabis

    • Testing the Interactive Effects of Delta-9-Tetrahydrocannabinol and Pregnenolone: LINK

    • Testing the Interactive Effects of Delta-9-Tetrahydrocannabinol and Pregnenolone: Sub-Study I: LINK

    • Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids - a PET Study: LINK

    • N-acetylcysteine Effects on Tetrahydrocannabinol: LINK

    • The Effects of ∆-9-THC and Naloxone in Humans: LINK

    • The Effects of Cannabidiol and ∆-9-THC in Humans: LINK

  • MDMA

    • Effect of Methylenedioxymethamphetamine (MDMA) (Serotonin Release) on Fear Extinction: LINK

    • Role of Dopamine, Serotonin and 5-HT2A Receptors in Emotion Processing: LINK

  • Psilocybin

    • Direct Comparison of Altered States of Consciousness Induced by LSD and Psilocybin in a Random-order Placebo-controlled Cross-over Study in Healthy Subjects: LINK

    • Persisting Effects of Psilocybin: LINK

    • The Effects of Psilocybin-Facilitated Experience on the Psychology and Effectiveness of Religious Professionals (NYU): LINK

    • Effects of Psilocybin-facilitated Experience on the Psychology and Effectiveness of Professional Leaders in Religion (Johns Hopkins): LINK

    • Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators: LINK

    • The Neurobiological Effect of 5-HT2AR Modulation: LINK

    • Characterization of Altered Waking States of Consciousness in Healthy Humans: LINK

    • Effects of SERT Inhibition on the Subjective Response to Psilocybin in Healthy Subjects: LINK

    • Visual Surround Suppression and Perceptual Expectation Under Psilocybin: LINK

  • Salvinorin A

    • Effects of Salvinorin A in Healthy Controls: LINK

      
      

• Patients with Diagnosed Disorders/Diseases

  • Alzheimer's Disease

    • Cannabis

      • Trial of Dronabinol Adjunctive Treatment of Agitation in Alzheimer's Disease (AD) (THC-AD)

  • Anorexia Nervosa

    • Psilocybin

      • Effects of Psilocybin in Anorexia Nervosa

  • Anxiety

    • Cannabis

      • Study of Dronabinol Treatment for Depression and/or Anxiety in Older Patients

    • LSD

      • LSD Treatment in Persons Suffering From Anxiety Symptoms in Severe Somatic Diseases or in Psychiatric Anxiety Disorders

    • Psilocybin

      • Psilocybin Cancer Anxiety Study

  • Autism spectrum disorder

    • Cannabis

      • Cannabinoids for Behavioral Problems in Children With ASD

  • Bipolar disorder

    • Cannabis

      • Cognitive and Psychophysiological Effects of Delta-9-Tetrahydrocannabinol in Bipolar Disorder

  • Depression

    • Cannabis

      • Study of Dronabinol Treatment for Depression and/or Anxiety in Older Patients

    • LSD

      • LSD Therapy for Persons Suffering From Major Depression (LAD)

    • Psilocybin

      • Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder

      • Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative Mechanisms

      • Psilocybin and Depression

      • Effects of Psilocybin in Major Depressive Disorder

      • Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors

      • Clinical, Neurocognitive, and Emotional Effects of Psilocybin in Depressed Patients - Proof of Concept

      • The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression (P-TRD)

      • A Study of Psilocybin for Major Depressive Disorder (MDD)

      • Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

  • Familial Dysautonomia

    • Cannabis

      • The Safety, Tolerability and Efficacy of Dronabinol, for the Treatment of Nausea and Vomiting in Familial Dysautonomia

  • Migraines/Cluster Headaches

    • Psilocybin

      • Psilocybin for the Treatment of Migraine Headache

      • Psilocybin for the Treatment of Cluster Headache

      • Effects of Psilocybin in Post-Traumatic Headache

  • Obsessive compulsive disorder

    • Cannabis

      • Cannabinoid Medication for Adults With OCD

    • Psilocybin

      • Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.

      • Psilocybin for Treatment of Obsessive Compulsive Disorder

  • Pain

    • Cannabis

      • Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial

      • Treatment of Chronic Pain With Cannabidiol (CBD) and Delta-9-tetrahydrocannabinol (THC)

      • Trial of Dronabinol and Vaporized Cannabis in Neuropathic Low Back Pain

      • Investigation of Cannabinoid Receptor Agonist Dronabinol in Patients With Functional Chest Pain

  • Post-traumatic stress disorder

    • Cannabis

      • Effects of Delta-9 Tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R61 Study

      • Cannabinoid Control of Fear Extinction Neural Circuits in Post-traumatic Stress Disorder

    • MDMA

      • A Multi-Site Study of MDMA-Assisted Psychotherapy for PTSD

      • Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD

      • Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD

      • Evaluation of MDMA on Startle Response

  • Psychosis

    • Cannabis

      • Probing the Cannabinoid System in Individuals With a Family History of Psychosis

      • Cannabis, Schizophrenia and Reward: Self-Medication and Agonist Treatment?

  • Sleep disorders

    • Cannabis

      • Tetrahydrocannabinol (THC) and Sleep

  • Substance use

    • Cannabis

      • A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking

    • Ibogaine

      • Ibogaine in the Treatment of Alcoholism: a Randomized, Double-blind, Placebo-controlled, Escalating-dose, Phase 2 Trial

    • Psilocybin

      • A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence

      • Psilocybin-facilitated Treatment for Cocaine Use

      • Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study

      • Psilocybin-assisted Psychotherapy for Opioid Use Disorder

  • Tourette Syndrome

    • Cannabis

      • Efficacy of a Therapeutic Combination of Dronabinol and PEA for Tourette Syndrome

  • Trichotillomania

    • Cannabis

      • Dronabinol in Trichotillomania